Symptoms and Transmission 
Mpox occurs in three stages. After an incubation period of approximately 1–2 weeks, a prodrome, characterized by fever and lymphadenopathy occurs, which is followed by the onset of a deep-seated vesicular or pustular rash that often begins centrally and spreads to the limbs.

Transmission of Mpox can occur through direct contact with the infectious rash, scabs, or body fluids, through respiratory secretions during prolonged face-to-face contact or intimate physical contact, or through touching items, such as clothing or linens, that previously touched a patient’s infectious rash or body fluids. Patients are considered contagious until the scabs have crusted over and fallen off and a fresh layer of intact skin has formed underneath.